作者：(英)H.P.兰格(H.P.Rang)
页数：763
出版社：人民卫生出版社
出版日期：2018
ISBN：9787117255301
电子书格式：pdf/epub/txt
内容简介
根据教育部相关文件规定，为满足医学院校临床医学专业双语教学和来华留学生教学的需要，在调研、论证的基础上组织编写本套教材。本教材为英文版规划教材之一，在引进外版教材的基础上，根据我国教学实际情况进行改编，以使知识体系和主要内容基本符合教学大纲的要求。
目录
SECTION 1: GENERAL PRINCI-PLES
1.What is pharmacology?
OVERVIEW
WHAT IS A DRUG?
ORIGINS AND ANTECEDENTS
PHARMACOLOGY IN THE 20th AND 21 st CENTURIES
2.How drugs act: general principles
OVERVIEW
INTRODUCTION
PROTEIN TARGETS FOR DRUG BINDING
DESENSITISATION AND TOLERANCE
QUANTITATIVE ASPECTS OF DRUG-RECEPTOR INTERACTIONS
THE NATURE OF DRUG EFFECTS
3.How drugs act: molecular aspects
OVERVIEW
TARGETS FOR DRUG ACTION
RECEPTOR PROTEINS
ION CHANNELS AS DRUG TARGETS
CONTROL OF RECEPTOR EXPRESSION
RECEPTORS AND DISEASE
4.How drugs act: cellular aspects-excitation,contraction and secretion
OVERVIEW
REGULATION OF INTRACELLULAR CALCIUM
EXCITATION
MUSCLE CONTRACTION
RELEASE OF CHEMICAL MEDIATORS
EPITHELIAL ION TRANSPORT
5.Cellular mechanisms: Host defense
OVERVIEW
INTRODUCTION
THE INNATE IMMUNE RESPONSE
THE ADAPTIVE IMMUNE RESPONSE
SYSTEMIC RESPONSES IN INFLAMMATION
6. Absorption and distribution of drugs
OVERVIEW
INTRODUCTION
PHYSICAL PROCESSES UNDERLYING DRUG DISPOSITION
DRUG ABSORPTION AND ROUTES OF ADMINISTRATION
DISTRIBUTION OF DRUGS IN THE BODY
SPECIAL DRUG DELIVERY SYSTEMS
7.Drug metabolism and elimination
OVERVIEW
INTRODUCTION
DRUG METABOLISM
EXCRETION OF THE DRUG AND ITS METABOLITES
8.Pharmacokinetics
OVERVIEW
INTRODUCTION: DEFINITION AND USES OF PHARMACOKINETICS
DRUG ELIMINATION EXPRESSED AS CLEARANCE
SINGLE-COMPARTMENT MODEL
MORE COMPLICATED KINETIC MODELS
POPULATION PHARMACOKINETICS
LIMITATIONS OF PHARMACOKINETICS
SECTION 2:CHEMICAL MEDI-ATORS
SECTION 3:DRUGS AFFECTING MAJOR ORGAN SYSTEMS
SECTION 4:NERVOUS SYSTEM
SECTION 5:DRUGS USED FOR THE TREATMENT OF INFEC-TIONS AND CANCER
Index
1.What is pharmacology?
OVERVIEW
WHAT IS A DRUG?
ORIGINS AND ANTECEDENTS
PHARMACOLOGY IN THE 20th AND 21 st CENTURIES
2.How drugs act: general principles
OVERVIEW
INTRODUCTION
PROTEIN TARGETS FOR DRUG BINDING
DESENSITISATION AND TOLERANCE
QUANTITATIVE ASPECTS OF DRUG-RECEPTOR INTERACTIONS
THE NATURE OF DRUG EFFECTS
3.How drugs act: molecular aspects
OVERVIEW
TARGETS FOR DRUG ACTION
RECEPTOR PROTEINS
ION CHANNELS AS DRUG TARGETS
CONTROL OF RECEPTOR EXPRESSION
RECEPTORS AND DISEASE
4.How drugs act: cellular aspects-excitation,contraction and secretion
OVERVIEW
REGULATION OF INTRACELLULAR CALCIUM
EXCITATION
MUSCLE CONTRACTION
RELEASE OF CHEMICAL MEDIATORS
EPITHELIAL ION TRANSPORT
5.Cellular mechanisms: Host defense
OVERVIEW
INTRODUCTION
THE INNATE IMMUNE RESPONSE
THE ADAPTIVE IMMUNE RESPONSE
SYSTEMIC RESPONSES IN INFLAMMATION
6. Absorption and distribution of drugs
OVERVIEW
INTRODUCTION
PHYSICAL PROCESSES UNDERLYING DRUG DISPOSITION
DRUG ABSORPTION AND ROUTES OF ADMINISTRATION
DISTRIBUTION OF DRUGS IN THE BODY
SPECIAL DRUG DELIVERY SYSTEMS
7.Drug metabolism and elimination
OVERVIEW
INTRODUCTION
DRUG METABOLISM
EXCRETION OF THE DRUG AND ITS METABOLITES
8.Pharmacokinetics
OVERVIEW
INTRODUCTION: DEFINITION AND USES OF PHARMACOKINETICS
DRUG ELIMINATION EXPRESSED AS CLEARANCE
SINGLE-COMPARTMENT MODEL
MORE COMPLICATED KINETIC MODELS
POPULATION PHARMACOKINETICS
LIMITATIONS OF PHARMACOKINETICS
SECTION 2:CHEMICAL MEDI-ATORS
SECTION 3:DRUGS AFFECTING MAJOR ORGAN SYSTEMS
SECTION 4:NERVOUS SYSTEM
SECTION 5:DRUGS USED FOR THE TREATMENT OF INFEC-TIONS AND CANCER
Index
