作者：冯传良 窦晓秋 徐亦斌
页数：196
出版社：上海交通大学出版社
出版日期：2021
ISBN：9787313220998
电子书格式：pdf/epub/txt
内容简介
对外场有响应能力的智能合成材料是目前引起科研兴趣的新兴研究领域，也会面临许多大的挑战，但是高分子材料由于具有结构可设计性、功能可调的特点使其将来在开发基于智能高分子材料的生物材料、检测材料等方面显示出了巨大的潜力。因此，针对智能高分子及其潜在应用这一热点研究领域，本课程对研究生讲授介绍高分子材料，尤其酸碱响应性高分子材料的设计、制备、及其微纳米结构修饰等领域，包含未来的发展趋势等。以达到使学生对外场响应高分子合成制备、修饰及应用等有深刻的理解和认识，也为将来培养在该领域的研究和应用型人才做准备。具体的课程内容包括三大部分：微纳米结构制备的进展和现状；酸碱响应性高分子材料的制备、组装、修饰、表征等；微纳米结构修饰的智能高分子材料的未来发展及前景。
作者简介
冯传良：上海交通大学材料科学与工程学院长聘教授，科技部中青年创新领军人才，教育部新世纪优秀人才，上海市东方学者。2005年荷兰特温特大学化工系博士毕业，2006-2008.3德国马普高分子所博士后，2008.4-2009.7荷兰格罗宁根大学Biomade研究所研究员，2009.8上海交通大学材料学院教授。研究方向为组织修复、再生医学生物材料的构筑及应用研究。先后主持国家自然科学基金重点项目，上海市教委创新研究重大项目等20余项。共发表论文120余篇，其中以通讯作者发表包括Acc. Chem. Res., Adv. Mater.，Angew. Chem. Int. Ed., J. Am. Chem. Soc.等SCI论文80余篇，申请国家发明专利15项，授权专利6项。任European Polymer Journal客座主编和Advanced Composited and Hybrid Materials期刊编委。获国际纯粹化学与应用联合会Richard R Ernst国际学术奖。
目录
Chapter 1 Reactive Platforms for Controllable Fabrication of Functional
(Bio)Interfaces
1.1 Scope of Surface Modification for (Bio)Reactive Platfor ms
and Functional (Bio)Interfaces
1.2 Chemical and Topographical Pattern Fabrication
from Micrometer to Nanometer Length Scales
References
Chapter 2 Surface Reactions and Fabrication of Bioreactive Platforms
Based on Organic and Polymeric Films: From Micrometer
to Nanometer Length Scale
2.1 Introduction: Bioreactive Platforms and Biointerfaces
via Organic and Polymeric Films
2.1.1 Organic and Polymeric Films
2.1.2 Pattern Fabrication on Organic and Polymeric Films
2.2 Surface Reactions of Organic and Polymeric Films
2.2.1 Self-assembled Monolayers
2.2.2 Surface Modification with Polymers
2.3 Patterned Organic and Polymeric Films for Tailored
(Bio)Interfaces
2.3.1 Microcontact Printing
2.3.2 Selective Molecular Assembly Patterning (SMAP)
2.3.3 Embossing and Nano-Imprinting
2.3.4 Self-assembled Block Copoly mer Patterns
References
Chapter 3 Confinement Effects on the Reactivity in Ultrathin Polymer
Films: Kinetics and Temperature Dependence of the Hydrolysis
of NHS and TBA Esters
3.1 Introduction
3.2 Ultrathin PNHSMA Polymer Films
3.2.1 Characterization of the Hydrolysis of PNHSMA Films
3.2.2 Temperature Dependence of Reaction Kinetics
3.2.3 Comparison of Surface Reactions in SAMs
and Ultrathin Polymer Films
3.3 Ultrathin PS_-b-PiBA_ Polvmer Films
3.3.1 Characterization of Polymer Thin Film Surface
Composition
3.3.2 Characterization and Kinetics of the Hydrolysis
of PSm-b-PtBA, Films
3.3.3 Investigation of the Temperature Dependence
of Reaction Kinetics
3.3.4 Effects of Film Thickness and Thermal Pretreatment
on Reaction Rates
3.3.5 Dependence of Hydrolysis Kinetics on Surface
Composition
3.3.6 Comparison of Reactivity of T-Butyl Esters
in PS,-b-PtBAm Thin Films and in Solution
3.4 Experimental Section
References
Chapter 4 Reactive Thin Polymer Films as Platfor ms
for the Immobilization of Biomolecules
4.1 Introduction
4.2 Investigation of the Reactivity of PNHS MA
4.2.1 Coupling of PEGsoo-NH2
4.2.2 Coupling of Fluoresceinamine and BSA to PNHSMA
Films1wvve
4.2.3 Comparison of Surface Reactions on PNHSMA Films
and NHS-C10 Monolayers
4.3 Swelling Behavior and Stability of PNHSMA Films
4.4 Immobilization of DNA and Surface-Based Hybridization
4.4.1 DNA Immobilization Studied by SPR
4.4.2 Investigation of DNA Hybridization by SPFS
and Fluorescence Microscopy
4.5 Toward the Detection of Pathogenic Bacteria on PNHSMA
Films
4.6 Experimental Section
References
Chapter 5 Tailored Biointerfaces via Derivatization
of Polystyrene-b-Poly(Tert-Butyl Acrylate) Thin Films
5.1 Introduction
5.2 Investigation of the Surface Chemistry of PS690-b-PtBA1210
Films
5.2.1 Surface Hydrolysis of PS690-b-PtBA1210 Films
5.2.2 Covalent Coupling of PEG to Activated
PSkon-b-PtBA n Films
5.3 Covalent Coupling of Biomolecules to Activated
PS690-b-PtBA1210 Films
5.4 Cell Adhesion Studies on PSs90-b-PtBA1210 Films
5.5 Experimental Section
References
Chapter 6 Fabrication of Robust Biomolecular Patterns by Reactive
Microcontact Printing on NHS Ester Containing Polymer Films
6.1 Introduction
6.2 Approaches for Micropatterning of PNHSMA Films
6.3 Functionalization of PNHSMA Films by Reactive u.CP
6.4 Non-specific Adsorption (NSA)
6.5 Patterning of PNHSMA and Coupling of (Bio)Molecules
to Patterned Films
6.6 DNA Hybridization
6.7 Experimental Section
References
Chapter 7 Reactive uCP on Ultrathin Block Copolymer Films
Investigation of the uCP Mechanism and Applications
to Sub-um (Bio)Molecular Patterning
7.1 Introduction
7.2 Strategy A: Fabrication of Multimo
(Bio)Interfaces
1.1 Scope of Surface Modification for (Bio)Reactive Platfor ms
and Functional (Bio)Interfaces
1.2 Chemical and Topographical Pattern Fabrication
from Micrometer to Nanometer Length Scales
References
Chapter 2 Surface Reactions and Fabrication of Bioreactive Platforms
Based on Organic and Polymeric Films: From Micrometer
to Nanometer Length Scale
2.1 Introduction: Bioreactive Platforms and Biointerfaces
via Organic and Polymeric Films
2.1.1 Organic and Polymeric Films
2.1.2 Pattern Fabrication on Organic and Polymeric Films
2.2 Surface Reactions of Organic and Polymeric Films
2.2.1 Self-assembled Monolayers
2.2.2 Surface Modification with Polymers
2.3 Patterned Organic and Polymeric Films for Tailored
(Bio)Interfaces
2.3.1 Microcontact Printing
2.3.2 Selective Molecular Assembly Patterning (SMAP)
2.3.3 Embossing and Nano-Imprinting
2.3.4 Self-assembled Block Copoly mer Patterns
References
Chapter 3 Confinement Effects on the Reactivity in Ultrathin Polymer
Films: Kinetics and Temperature Dependence of the Hydrolysis
of NHS and TBA Esters
3.1 Introduction
3.2 Ultrathin PNHSMA Polymer Films
3.2.1 Characterization of the Hydrolysis of PNHSMA Films
3.2.2 Temperature Dependence of Reaction Kinetics
3.2.3 Comparison of Surface Reactions in SAMs
and Ultrathin Polymer Films
3.3 Ultrathin PS_-b-PiBA_ Polvmer Films
3.3.1 Characterization of Polymer Thin Film Surface
Composition
3.3.2 Characterization and Kinetics of the Hydrolysis
of PSm-b-PtBA, Films
3.3.3 Investigation of the Temperature Dependence
of Reaction Kinetics
3.3.4 Effects of Film Thickness and Thermal Pretreatment
on Reaction Rates
3.3.5 Dependence of Hydrolysis Kinetics on Surface
Composition
3.3.6 Comparison of Reactivity of T-Butyl Esters
in PS,-b-PtBAm Thin Films and in Solution
3.4 Experimental Section
References
Chapter 4 Reactive Thin Polymer Films as Platfor ms
for the Immobilization of Biomolecules
4.1 Introduction
4.2 Investigation of the Reactivity of PNHS MA
4.2.1 Coupling of PEGsoo-NH2
4.2.2 Coupling of Fluoresceinamine and BSA to PNHSMA
Films1wvve
4.2.3 Comparison of Surface Reactions on PNHSMA Films
and NHS-C10 Monolayers
4.3 Swelling Behavior and Stability of PNHSMA Films
4.4 Immobilization of DNA and Surface-Based Hybridization
4.4.1 DNA Immobilization Studied by SPR
4.4.2 Investigation of DNA Hybridization by SPFS
and Fluorescence Microscopy
4.5 Toward the Detection of Pathogenic Bacteria on PNHSMA
Films
4.6 Experimental Section
References
Chapter 5 Tailored Biointerfaces via Derivatization
of Polystyrene-b-Poly(Tert-Butyl Acrylate) Thin Films
5.1 Introduction
5.2 Investigation of the Surface Chemistry of PS690-b-PtBA1210
Films
5.2.1 Surface Hydrolysis of PS690-b-PtBA1210 Films
5.2.2 Covalent Coupling of PEG to Activated
PSkon-b-PtBA n Films
5.3 Covalent Coupling of Biomolecules to Activated
PS690-b-PtBA1210 Films
5.4 Cell Adhesion Studies on PSs90-b-PtBA1210 Films
5.5 Experimental Section
References
Chapter 6 Fabrication of Robust Biomolecular Patterns by Reactive
Microcontact Printing on NHS Ester Containing Polymer Films
6.1 Introduction
6.2 Approaches for Micropatterning of PNHSMA Films
6.3 Functionalization of PNHSMA Films by Reactive u.CP
6.4 Non-specific Adsorption (NSA)
6.5 Patterning of PNHSMA and Coupling of (Bio)Molecules
to Patterned Films
6.6 DNA Hybridization
6.7 Experimental Section
References
Chapter 7 Reactive uCP on Ultrathin Block Copolymer Films
Investigation of the uCP Mechanism and Applications
to Sub-um (Bio)Molecular Patterning
7.1 Introduction
7.2 Strategy A: Fabrication of Multimo
