作者：寇现娟
页数：184
出版社：华中科技大学出版社
出版日期：2017
ISBN：9787568043007
电子书格式：pdf/epub/txt
内容简介
蛇葡萄素（Ampelopsin）又名双氢杨梅素（dihydromyricetin，DMY）是藤茶中一种重要的黄酮类物质。研究表明，Ampelopsin具有广泛的生物学功能：抗炎、抗氧化、抗肿瘤、保肝、改善运动疲劳等。本书首从Ampelopsin的结构入手，然后分章节来探讨Ampelopsin的抗炎、抗氧化、抗肿瘤、保肝、神经保护、改善运动疲劳及衰老性肌萎缩的作用；阐明Ampelopsin发挥上述作用的信号分子或者靶标；Ampelopsin发展成为功能性食品的前景。
作者简介
寇现娟，女，副教授。健康科学学院运动医学教研室教师。郑州大学医学院生物化学与分子生物学专业硕士，华中科技大学同济医学院生物化学与分子生物学专业博士。
本书特色
蛇葡萄素（Ampelopsin）又名双氢杨梅素（dihydromyricetin，DMY）是藤茶中一种重要的黄酮类物质。研究表明，Ampelopsin具有广泛的生物学功能：抗炎、抗氧化、抗肿瘤、保肝、改善运动疲劳等。
本书首从Ampelopsin的结构入手，然后分章节来探讨Ampelopsin的抗炎、抗氧化、抗肿瘤、保肝、神经保护、改善运动疲劳及衰老性肌萎缩的作用；阐明Ampelopsin发挥上述作用的信号分子或者靶标；Ampelopsin发展成为功能性食品的前景。
目录
The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROS瞞ediated
activation of PI3K/Akt/NFκB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2睞RE pathway23
Chapter 4Anti瞭umor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways：involvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2瞚nduced apoptosis by ERK and Akt signaling
pathways and up瞨egulation of heme oxygenase159
5.2Ampelopsin attenuates 6睴HDA瞚nduced neurotoxicity by regulating
GSK3β/NRF2/ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80
6.3Ampelopsin attenuates brain aging of D瞘al瞚nduced rats through miR34a瞞ediated SIRT1/mTOR signaling pathway89
6.4Swimming attenuates D瞘alactose瞚nduced brain aging via suppressing miR34a瞞ediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130a瞞ediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNA瞨egulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates D瞘al瞚nduced oxidative stress瞨elated skeletal muscle atrophy through activating AMPK/SIRT1/PGC1α signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROS瞞ediated
activation of PI3K/Akt/NFκB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2睞RE pathway23
Chapter 4Anti瞭umor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways：involvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2瞚nduced apoptosis by ERK and Akt signaling
pathways and up瞨egulation of heme oxygenase159
5.2Ampelopsin attenuates 6睴HDA瞚nduced neurotoxicity by regulating
GSK3β/NRF2/ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80
6.3Ampelopsin attenuates brain aging of D瞘al瞚nduced rats through miR34a瞞ediated SIRT1/mTOR signaling pathway89
6.4Swimming attenuates D瞘alactose瞚nduced brain aging via suppressing miR34a瞞ediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130a瞞ediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNA瞨egulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates D瞘al瞚nduced oxidative stress瞨elated skeletal muscle atrophy through activating AMPK/SIRT1/PGC1α signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156
